A quarta temporada de Two and a Half Men foi transmitida entre setembro de 2006 e maio de 2007 pelo canal CBS.
4 - 1Working for Caligula Sep. 18, 2006
4 - 2Who's Vod Kanockers? Sep. 25, 2006
4 - 3The Sea is a Harsh Mistress Oct. 02, 2006
4 - 4A Pot Smoking Monkey Oct. 09, 2006
4 - 5A Live Woman of Proven Fertility Oct. 16, 2006
4 - 6Apologies for the Frivolity Oct. 23, 2006
4 - 7Repeated Blows to His Unformed Head Nov. 06, 2006
4 - 8Release the Dogs Nov. 13, 2006
4 - 9Corey's Been Dead For an Hour Nov. 20, 2006
4 - 10Kissing Abraham Lincoln Nov. 27, 2006
4 - 11Walnuts and Demerol Dec. 11, 2006
4 - 12Castrating Sheep in Montana Jan. 08, 2007
4 - 13Don't Worry, Speed Racer Jan. 22, 2007
4 - 14That's Summer Sausage, Not Salami Feb. 05, 2007
4 - 15My Damn Stalker Feb. 12, 2007
4 - 16Young People Have Phlegm Too Feb. 18, 2007
4 - 17I Merely Slept With a Commie Feb. 26, 2007
4 - 18It Never Rains in Hooterville Mar. 19, 2007
4 - 19Smooth as a Ken Doll Apr. 09, 2007
4 - 20Aunt Myra Doesn't Pee a Lot Apr. 16, 2007
4 - 21Tucked, Taped and Gorgeous Apr. 23, 2007
4 - 22Mr. McGlue's Feedbag Apr. 30, 2007
4 - 23Anteaters. They're Just Crazy-lookin May. 07, 2007
4 - 24Prostitutes and Gelato May. 14, 2007